GLP-1 Therapy: A New Era in Weight Management for South Africans

Discover how modern GLP-1 therapies, guided by Udok’s connected care approach, are helping South Africans achieve lasting weight loss under professional medical supervision.

Ophthalmologist's Department

A growing challenge

Obesity and excess weight have become some of the most pressing health challenges in South Africa.
According to the South African Demographic and Health Survey, nearly two-thirds of women and one-third of men in the country are classified as overweight or obese. This increases the risk of type 2 diabetes, hypertension, heart disease, sleep apnoea, and other chronic conditions that impact quality of life and healthcare costs.

While eating healthier and staying active remain essential to weight management, many South Africans struggle to achieve and maintain meaningful weight loss through lifestyle changes alone.
That’s where medical innovation, supported by professional guidance, can make a real difference.

Introducing GLP-1 receptor agonists

GLP-1 receptor agonists (often abbreviated as GLP-1 RAs) are a new class of medications that are transforming how doctors approach weight management.
Originally developed for diabetes treatment, they’ve shown remarkable results in helping people lose weight safely and effectively.

These medications mimic a natural hormone in the body called glucagon-like peptide-1 (GLP-1). This hormone plays a key role in regulating appetite, slowing digestion, and improving how your body uses insulin. As a result, patients tend to feel full sooner, eat less, and experience steady weight loss over time.

Who qualifies for GLP-1 therapy?

GLP-1 therapy is not a quick fix — it’s a medical treatment designed for people who meet certain health criteria.


In South Africa, doctors generally recommend GLP-1 medication for adults who meet one of the following:

  • Have a Body Mass Index (BMI) of 27 or higher with at least one weight-related risk factor such as high blood pressure, high cholesterol, insulin resistance, or sleep apnoea.
  • Have a BMI of 30 or higher, even without additional health risks

It’s important to note that GLP-1 medication should always be prescribed and monitored by a qualified healthcare professional. Treatment works best when combined with a healthy diet, regular physical activity, and behavioural support — not as a substitute for them.

The benefits of GLP-1 treatment

Clinical studies have shown that people using GLP-1 medication can lose 10–15% of their body weight when combined with lifestyle changes.


But the benefits go beyond weight loss:

  • Better blood sugar control and reduced insulin resistance.
  • Lower blood pressure and improved cholesterol levels.
  • Reduced risk of developing type 2 diabetes and heart disease.
  • Improved energy, sleep, and quality of life
    These results make GLP-1 therapies one of the most promising tools in modern weight management and chronic disease prevention.

Understanding the risks

As with any medical treatment, GLP-1 medications have potential side effects and are not suitable for everyone.
The most common side effects are mild and temporary, including nausea, bloating, diarrhoea, or constipation — especially when starting or increasing the dose.

Other important safety considerations include:

  • Rare risk of pancreatitis or gallbladder problems.
  • Not recommended during pregnancy or breastfeeding.
  • Contraindicated for anyone with a personal or family history of certain thyroid cancers (such as medullary thyroid carcinoma).
  • Only use medicine prescribed by a doctor — avoid unregulated or online sources.

Your doctor will help assess whether GLP-1 therapy is right for you and monitor your response over time.

The Udok approach to medical weight management

At Udok, we believe sustainable weight management is a journey — not a single prescription.
Our approach combines technology, medical expertise, and patient support to help South Africans achieve better health outcomes.

Through our telehealth platform, you can:

  • Consult a licensed doctor online from your home or pharmacy clinic.
  • Access GLP-1 therapy where clinically appropriate, with professional supervision.
  • Track progress remotely, including weight, symptoms, and side effects.
  • Receive nutritional and lifestyle guidance from healthcare professionals.

Our integrated care model ensures that medication is just one part of a holistic treatment plan focused on long-term wellbeing.

Is GLP-1 therapy right for you?

If you’ve struggled to lose weight despite genuine effort with diet and exercise, or if you have health conditions linked to your weight, GLP-1 therapy may be worth discussing.
The first step is a comprehensive online consultation with a Udok doctor who can assess your eligibility, explain the benefits and risks, and design a personalised plan.

Take control of your health with Udok

Modern medicine has given us powerful new tools to fight obesity and its complications.
With the right medical support and lifestyle changes, lasting results are possible.

To register as a patient, click the button below and begin your journey to better health, anywhere, anytime.

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